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Vitreoretinal degeneration, or dominant hyaloideoretinal dystrophy of Wagner, VCAN-related vitreoretinopathy, vitreoretinal degeneration, Wagner type or Wagner syndrome, is a hereditary eye disorder that soon leads to vision loss. This eye disorder is characterised by the clear thick gel (the vitrous) develops into a thin layer. Vitreoretinal degeneration is caused by genetic changes in the VCAN gene and is inherited in an autosomal manner.[1]