 Ethinylestradiol | |
 Drospirenone | |
| Combination of | |
|---|---|
| Drospirenone | Progestogen; Progestin; Antimineralocorticoid; Antiandrogen |
| Ethinylestradiol | Estrogen |
| Levomefolic acid | Vitamin |
| Clinical data | |
| Trade names | Beyaz, Safyral,[1] Tydemy[2] |
| Other names | EE/DRSP/LMF; EE/DRSP/THF; EE/DRSP/THFA; EE/DRSP/FH4; EE/DRSP/VB9 |
| MedlinePlus | a601050 |
| License data | |
| Routes of administration | By mouth |
| Legal status | |
| Legal status |
|
| Identifiers | |
| ChemSpider |
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| KEGG | |
| (verify) | |
Drospirenone/ethinylestradiol/levomefolic acid (EE/DRSP/LMF), sold under the brand name Beyaz among others, is a combination of ethinylestradiol (EE), an estrogen, drospirenone (DRSP), a progestogen, antimineralocorticoid, and antiandrogen, and levomefolic acid (LMF), a form of vitamin B9, which is used as a birth control pill to prevent pregnancy in women. The formulation contains folate as the calcium salt of levomefolic acid to lower the risk of complications such as fetal neural tube defects should the medication fail as a form of birth control.[3] EE/DRSP/LMF was approved for use by the US Food and Drug Administration (FDA) in September 2010.[3][4]
In 2021, it was the 277th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.[5][6]
- ^ "Safyral- drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium kit". DailyMed. 8 August 2017. Retrieved 14 August 2020.
- ^ "Tydemy- drospirenone, ethinyl estradiol and levomefolate calcium and levomefolate calcium kit". DailyMed. 26 November 2019. Retrieved 14 August 2020.
- ^ a b "FDA approves combination contraceptive containing a folate" (Press release). U.S. Food and Drug Administration (FDA). 24 September 2010. Retrieved 6 February 2011.
- ^ "Drug Approval Package: Beyaz (drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium) NDA #022532". U.S. Food and Drug Administration (FDA). 4 April 2011. Retrieved 14 August 2020.
"Application Number: 022532sOrig1s000" (PDF) (Summary Review). Center for Drug Evaluation and Research. 24 September 2010. - ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Drospirenone; EthinylEstradiol; Levomefolate - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.