Duocarmycin

The duocarmycins are members of a series of related natural products first isolated from Streptomyces bacteria in 1978.[1][2][3] They are notable for their extreme cytotoxicity and thus represent a class of exceptionally potent antitumour antibiotics.[4][5]

  1. ^ Yasuzawa, Tohru; Iida, Takao; Muroi, Ken'Ichi; Ichimura, Michio; Takahashi, Keiichi; Sano, Hiroshi (1988). "Structures of Duocarmycins, novel antitumor antibiotics produced by Streptomyces sp". Chemical & Pharmaceutical Bulletin. 36 (9): 3728–31. doi:10.1248/cpb.36.3728. PMID 3255306.
  2. ^ Takahashi, Isami; Takahashi, KEI-Ichi; Ichimura, Michio; Morimoto, Makoto; Asano, Kozo; Kawamoto, Isao; Tomita, Fusao; Nakano, Hirofumi (1988). "Duocarmycin A, a new antitumor antibiotic from Streptomyces". The Journal of Antibiotics. 41 (12): 1915–7. doi:10.7164/antibiotics.41.1915. PMID 3209484.
  3. ^ "Cytotoxic Agents". ADC Review/Journal of Antibody-drug Conjugates. October 29, 2013.
  4. ^ Boger, Dale L. (1991). "Duocarmycins: a new class of sequence selective DNA minor groove alkylating agents". Chemtracts: Organic Chemistry. 4 (5): 329–49.
  5. ^ Tercel, Moana; McManaway, Sarah P.; Leung, Euphemia; Liyanage, H. D. Sarath; Lu, Guo-Liang; Pruijn, Frederik B. (2013). "The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment". Angewandte Chemie International Edition. 52 (21): 5442–6. doi:10.1002/anie.201208373. PMID 23616474.