E2F1

E2F1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H24, 1O9K, 2AZE
Identifiers
Aliases	E2F1, E2F-1, RBAP1, RBBP3, RBP3, E2F transcription factor 1
External IDs	OMIM: 189971; MGI: 101941; HomoloGene: 3828; GeneCards: E2F1; OMA:E2F1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	33,686,385 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	154,411,812 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; secondary oocyte; ; ventricular zone; ; gonad; ; mucosa of transverse colon; ; stromal cell of endometrium; ; prefrontal cortex; ; testicle; ; bone marrow; ; putamen;
	Top expressed in
	zygote; ; secondary oocyte; ; ectoderm; ; otic vesicle; ; otic placode; ; primary oocyte; ; fetal liver hematopoietic progenitor cell; ; ventricular zone; ; saccule; ; gastrula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; transcription factor binding; protein binding; protein dimerization activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein kinase binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; transcription regulator complex; Rb-E2F complex; nucleus; mitochondrion; nucleoplasm; centrosome; protein-containing complex; RNA polymerase II transcription regulator complex;
Biological process	cellular response to nerve growth factor stimulus; negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; lens fiber cell apoptotic process; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; positive regulation of fibroblast proliferation; negative regulation of DNA binding; negative regulation of fat cell proliferation; DNA damage checkpoint signaling; cellular response to xenobiotic stimulus; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of cell cycle; positive regulation of transcription, DNA-templated; regulation of G1/S transition of mitotic cell cycle; mRNA stabilization; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of gene expression; cellular response to fatty acid; anoikis; spermatogenesis; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway by p53 class mediator; cell cycle; forebrain development; negative regulation of transcription, DNA-templated; cellular response to hypoxia; positive regulation of transcription by RNA polymerase II; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of transcription involved in G1/S transition of mitotic cell cycle; positive regulation of apoptotic process; negative regulation of G0 to G1 transition; positive regulation of glial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1869
	13555
	ENSG00000101412
	ENSMUSG00000027490
	Q01094
	Q61501
	NM_005225
	NM_007891; NM_001291105
	NP_005216
	NP_001278034; NP_031917
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101412 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027490 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG (December 1996). "Structure and partial genomic sequence of the human E2F1 gene". Gene. 173 (2): 163–9. doi:10.1016/0378-1119(96)00184-9. PMID 8964493.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101412 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027490 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8964493-5] Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG (December 1996). "Structure and partial genomic sequence of the human E2F1 gene". Gene. 173 (2): 163–9. doi:10.1016/0378-1119(96)00184-9. PMID 8964493.

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