E2F3

E2F3
Identifiers
Aliases	E2F3, E2F-3, E2F transcription factor 3
External IDs	OMIM: 600427; MGI: 1096340; HomoloGene: 74413; GeneCards: E2F3; OMA:E2F3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	20,493,714 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	30,170,046 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; tendon of biceps brachii; ; gingival epithelium; ; tibia; ; cartilage tissue; ; visceral pleura; ; bone marrow;
	Top expressed in
	primitive streak; ; mandibular prominence; ; maxillary prominence; ; cumulus cell; ; medullary collecting duct; ; abdominal wall; ; atrium; ; tail of embryo; ; hair follicle; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; protein dimerization activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription factor binding;
Cellular component	nucleus; transcription regulator complex; RNA polymerase II transcription regulator complex; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; negative regulation of fat cell proliferation; cell cycle; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of vascular associated smooth muscle cell apoptotic process; negative regulation of transcription by RNA polymerase II; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1871
	13557
	ENSG00000112242
	ENSMUSG00000016477
	O00716
	O35261
	NM_001243076; NM_001949
	NM_001289920; NM_010093; NM_001359994
	NP_001230005; NP_001940
	NP_001276849; NP_034223; NP_001346923
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112242 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016477 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Dec 1993). "The retinoblastoma protein binds to a family of E2F transcription factors". Molecular and Cellular Biology. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112242 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016477 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8246996-5] Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Dec 1993). "The retinoblastoma protein binds to a family of E2F transcription factors". Molecular and Cellular Biology. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996.

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