E4F1

E4F1
Identifiers
Aliases	E4F1, E4F, E4F transcription factor 1
External IDs	OMIM: 603022; MGI: 109530; HomoloGene: 3259; GeneCards: E4F1; OMA:E4F1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,235,742 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,689,287 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; sural nerve; ; right lobe of thyroid gland; ; granulocyte; ; left lobe of thyroid gland; ; pituitary gland; ; skin of leg; ; skin of abdomen; ; apex of heart; ; anterior pituitary;
	Top expressed in
	granulocyte; ; neural layer of retina; ; muscle of thigh; ; lip; ; right kidney; ; superior frontal gyrus; ; urethra; ; morula; ; morula; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; transcription coactivator activity; metal ion binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; cAMP response element binding; transferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; spindle; nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; cell division; DNA replication; regulation of mitotic cell cycle, embryonic; protein ubiquitination; regulation of growth; cell cycle; cell population proliferation; viral process; regulation of cell cycle process; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	1877
	13560
	ENSG00000167967
	ENSMUSG00000024137
	Q66K89
	Q8CCE9
	NM_001288776; NM_001288778; NM_004424
	NM_001301784; NM_007893; NM_001355708
	NP_001275705; NP_001275707; NP_004415
	NP_001288713; NP_031919; NP_001342637
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167967 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024137 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet. 82 (1–2): 99–100. doi:10.1159/000015075. PMID 9763670. S2CID 46826484.
^ Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res. 6 (6): 525–537. doi:10.1101/gr.6.6.525. PMID 8828041.
^ "Entrez Gene: E4F1 E4F transcription factor 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167967 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024137 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9763670-5] Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet. 82 (1–2): 99–100. doi:10.1159/000015075. PMID 9763670. S2CID 46826484.

[pmid8828041-6] Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res. 6 (6): 525–537. doi:10.1101/gr.6.6.525. PMID 8828041.

[entrez-7] "Entrez Gene: E4F1 E4F transcription factor 1".

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