EBF1

EBF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LYR, 3MQI
Identifiers
Aliases	EBF1, COE1, EBF, O/E-1, OLF1, early B-cell factor 1, early B cell factor 1, EBF transcription factor 1
External IDs	OMIM: 164343; MGI: 95275; HomoloGene: 7297; GeneCards: EBF1; OMA:EBF1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	159,099,916 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	45,008,091 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; synovial membrane; ; Achilles tendon; ; oocyte; ; buccal mucosa cell; ; skin of hip; ; cardiac muscle tissue of right atrium; ; parietal pleura; ; vena cava; ; spinal ganglia;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; trigeminal ganglion; ; superior cervical ganglion; ; spinal ganglia; ; neural tube; ; ankle; ; lumbar spinal ganglion; ; subcutaneous adipose tissue; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; DNA-binding transcription factor activity; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; C2H2 zinc finger domain binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1879
	13591
	ENSG00000164330
	ENSMUSG00000057098
	Q9UH73
	Q07802
NM_001290360; NM_024007; NM_182708; NM_001324101; NM_001324103;
	NM_001324106; NM_001324107; NM_001324108; NM_001324109; NM_001324111; NM_001364155; NM_001364156; NM_001364157; NM_001364158; NM_001364159
	NM_001290709; NM_001290710; NM_001290711; NM_007897
NP_001277289; NP_001311030; NP_001311032; NP_001311035; NP_001311036;
	NP_001311037; NP_001311038; NP_001311040; NP_076870; NP_874367; NP_001351084; NP_001351085; NP_001351086; NP_001351087; NP_001351088
NP_001277638; NP_001277639; NP_001277640; NP_031923; NP_001349498;
	NP_001349500; NP_001349503; NP_001349504; NP_001349505; NP_001349506; NP_001349507; NP_001349508
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.^[5]^[6]^[7]

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.^[8]^[9] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.^[10] In addition, EBF1 is also noted for its role in chondrogenic differentiation in limb bud mesenchymal progenitor cells.^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164330 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057098 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Symbol Report: EBF1". HUGO Gene Nomenclature Committee.
^ Milatovich A, Qiu RG, Grosschedl R, Francke U (April 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mammalian Genome. 5 (4): 211–215. doi:10.1007/BF00360547. PMID 8012110. S2CID 19839522.
^ "Entrez Gene: EBF1 early B-cell factor 1".
^ Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, et al. (May 2010). "Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin". Immunity. 32 (5): 714–725. doi:10.1016/j.immuni.2010.04.013. PMID 20451411.
^ Hagman J, Ramírez J, Lukin K (January 2012). "B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1". In Murre C (ed.). Epigenetic Regulation of Lymphocyte Development. Current Topics in Microbiology and Immunology. Vol. 356. pp. 17–38. doi:10.1007/82_2011_139. ISBN 978-3-642-24102-4. ISSN 0070-217X. PMC 3925327. PMID 21735360.
^ Schwartz AM, Putlyaeva LV, Covich M, Klepikova AV, Akulich KA, Vorontsov IE, et al. (October 2016). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004. PMID 27424222.
^ Takács R, Vágó J, Póliska S, Pushparaj PN, Ducza L, Kovács P, et al. (May 2023). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. PMC 10164575. PMID 36987858.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164330 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057098 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Symbol Report: EBF1". HUGO Gene Nomenclature Committee.

[pmid8012110-6] Milatovich A, Qiu RG, Grosschedl R, Francke U (April 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mammalian Genome. 5 (4): 211–215. doi:10.1007/BF00360547. PMID 8012110. S2CID 19839522.

[entrez-7] "Entrez Gene: EBF1 early B-cell factor 1".

[8] Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, et al. (May 2010). "Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin". Immunity. 32 (5): 714–725. doi:10.1016/j.immuni.2010.04.013. PMID 20451411.

[9] Hagman J, Ramírez J, Lukin K (January 2012). "B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1". In Murre C (ed.). Epigenetic Regulation of Lymphocyte Development. Current Topics in Microbiology and Immunology. Vol. 356. pp. 17–38. doi:10.1007/82_2011_139. ISBN 978-3-642-24102-4. ISSN 0070-217X. PMC 3925327. PMID 21735360.

[10] Schwartz AM, Putlyaeva LV, Covich M, Klepikova AV, Akulich KA, Vorontsov IE, et al. (October 2016). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004. PMID 27424222.

[11] Takács R, Vágó J, Póliska S, Pushparaj PN, Ducza L, Kovács P, et al. (May 2023). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. PMC 10164575. PMID 36987858.

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