EBI3

EBI3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	7U7N, 7Z0L, 7ZG0, 7ZXK, 8D85
Identifiers
Aliases	EBI3, IL-27B, IL27B, Epstein-Barr virus induced 3, IL35B
External IDs	OMIM: 605816; MGI: 1354171; HomoloGene: 4207; GeneCards: EBI3; OMA:EBI3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,237,528 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,264,022 bp
RNA expression pattern
	Top expressed in
	placenta; ; decidua; ; spleen; ; appendix; ; lymph node; ; gonad; ; gallbladder; ; right adrenal gland; ; C1 segment; ; right coronary artery;
	Top expressed in
	granulocyte; ; splanchnocranium; ; rib; ; hyoid bone; ; humerus; ; stroma of bone marrow; ; sphenoid bone; ; Meckel's cartilage; ; lesser wing of sphenoid bone; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; cytokine activity; interleukin-27 receptor binding; protein binding; ciliary neurotrophic factor receptor activity; cytokine binding;
Cellular component	extracellular region; plasma membrane; membrane; extracellular space; endoplasmic reticulum lumen; external side of plasma membrane; receptor complex; ciliary neurotrophic factor receptor complex; CNTFR-CLCF1 complex;
Biological process	T-helper 1 type immune response; T cell proliferation; humoral immune response; positive regulation of alpha-beta T cell proliferation; regulation of signaling receptor activity; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; ciliary neurotrophic factor-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10148
	50498
	ENSG00000105246
	ENSMUSG00000003206
	Q14213
	O35228
	NM_005755
	NM_015766
	NP_005746
	NP_056581
	Wikidata
View/Edit Human	View/Edit Mouse

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105246 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003206 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3".
^ Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC 189923. PMID 8551575.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105246 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003206 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3".

[pmid8551575-6] Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC 189923. PMID 8551575.

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