EDEM2

EDEM2
Identifiers
Aliases	EDEM2, C20orf31, C20orf49, bA4204.1, ER degradation enhancing alpha-mannosidase like protein 2
External IDs	OMIM: 610302; MGI: 1915540; HomoloGene: 10075; GeneCards: EDEM2; OMA:EDEM2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,147,336 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,571,395 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right lobe of liver; ; islet of Langerhans; ; right adrenal gland; ; body of pancreas; ; left adrenal gland; ; mucosa of transverse colon; ; decidua; ; right adrenal cortex;
	Top expressed in
	lacrimal gland; ; decidua; ; islet of Langerhans; ; salivary gland; ; parotid gland; ; crypt of lieberkuhn of small intestine; ; pyloric antrum; ; seminal vesicula; ; epithelium of stomach; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; catalytic activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; membrane; endoplasmic reticulum quality control compartment;
Biological process	endoplasmic reticulum unfolded protein response; mannose trimming involved in glycoprotein ERAD pathway; N-glycan processing; positive regulation of retrograde protein transport, ER to cytosol; response to unfolded protein; ubiquitin-dependent glycoprotein ERAD pathway; trimming of terminal mannose on B branch; trimming of terminal mannose on C branch; trimming of first mannose on A branch; trimming of second mannose on A branch;
	Sources:Amigo / QuickGO
Orthologs
	55741
	108687
	ENSG00000088298
	ENSMUSG00000038312
	Q9BV94
	Q8BJT9
	NM_001145025; NM_018217
	NM_145537
	NP_001138497; NP_060687
	NP_663512
	Wikidata
View/Edit Human	View/Edit Mouse

ER degradation-enhancing alpha-mannosidase-like 2 is an enzyme that in humans is encoded by the EDEM2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088298 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038312 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
^ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
^ "Entrez Gene: EDEM2 ER degradation enhancer, mannosidase alpha-like 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000088298 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038312 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15537790-5] Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.

[pmid15579471-6] Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.

[entrez-7] "Entrez Gene: EDEM2 ER degradation enhancer, mannosidase alpha-like 2".

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