EGLN3

EGLN3
Identifiers
Aliases	EGLN3, HIFP4H3, HIFPH3, PHD3, egl-9 family hypoxia inducible factor 3
External IDs	OMIM: 606426; MGI: 1932288; HomoloGene: 32531; GeneCards: EGLN3; OMA:EGLN3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q13.1 Start 33,924,227 bp[1] End 34,462,774 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C1 Start 54,225,767 bp[2] End 54,250,646 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen apex of heart left ventricle right auricle ventricular zone right uterine tube rectum C1 segment amygdala Top expressed in temporal muscle masseter muscle esophagus mucous cell of stomach conjunctival fornix digastric muscle epithelium of small intestine epithelium of stomach pyloric antrum sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 2-oxoglutarate-dependent dioxygenase activity iron ion binding L-ascorbic acid binding dioxygenase activity metal ion binding protein binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity peptidyl-proline 4-dioxygenase activity Cellular component nucleoplasm nucleus cytoplasm cytosol Biological process response to hypoxia regulation of neuron apoptotic process peptidyl-proline hydroxylation to 4-hydroxy-L-proline cellular response to DNA damage stimulus regulation of cell population proliferation regulation of transcription from RNA polymerase II promoter in response to hypoxia activation of cysteine-type endopeptidase activity involved in apoptotic process protein hydroxylation apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 112399 112407 Ensembl ENSG00000129521 ENSMUSG00000035105 UniProt Q9H6Z9 Q91UZ4 RefSeq (mRNA) NM_001308103 NM_022073 NM_028133 RefSeq (protein) NP_001295032 NP_071356 NP_082409 Location (UCSC) Chr 14: 33.92 – 34.46 Mb Chr 12: 54.23 – 54.25 Mb PubMed search [3] [4]
Wikidata
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Egl nine homolog 3 is a protein that in humans is encoded by the EGLN3 gene.^[5] ELGN3 is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.