EGR3

EGR3
Identifiers
Aliases	EGR3, EGR-3, PILOT, early growth response 3
External IDs	OMIM: 602419; MGI: 1306780; HomoloGene: 37923; GeneCards: EGR3; OMA:EGR3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,693,480 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,320,063 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; parietal pleura; ; gastric mucosa; ; mucosa of paranasal sinus; ; lactiferous duct; ; skin of arm; ; sural nerve; ; orbitofrontal cortex; ; frontal pole; ; periodontal fiber;
	Top expressed in
	prefrontal cortex; ; hair follicle; ; primary motor cortex; ; skin of abdomen; ; olfactory tubercle; ; skin of external ear; ; cingulate gyrus; ; nucleus accumbens; ; piriform cortex; ; temporal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; metal ion binding; DNA binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	circadian rhythm; endothelial cell chemotaxis; cell migration involved in sprouting angiogenesis; muscle organ development; regulation of transcription, DNA-templated; positive regulation of endothelial cell proliferation; cellular response to fibroblast growth factor stimulus; negative regulation of apoptotic process; cellular response to vascular endothelial growth factor stimulus; transcription, DNA-templated; neuromuscular synaptic transmission; peripheral nervous system development; positive regulation of T cell differentiation in thymus; regulation of gamma-delta T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; cellular response to growth factor stimulus;
	Sources:Amigo / QuickGO
Orthologs
	1960
	13655
	ENSG00000179388
	ENSMUSG00000033730
	Q06889
	P43300
	NM_001199880; NM_001199881; NM_004430
	NM_001289925; NM_001289927; NM_018781
	NP_001186809; NP_001186810; NP_004421
	NP_001276854; NP_001276856; NP_061251
	Wikidata
View/Edit Human	View/Edit Mouse

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.^[5]^[6]^[7]

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179388 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033730 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP (Aug 1991). "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors". Oncogene. 6 (6): 917–28. PMID 1906159.
^ Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem. 277 (22): 19482–19487. doi:10.1074/jbc.M201687200. PMID 11909874.
^ ^a ^b "Entrez Gene: EGR3 early growth response 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179388 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033730 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1906159-5] Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP (Aug 1991). "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors". Oncogene. 6 (6): 917–28. PMID 1906159.

[pmid11909874-6] Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem. 277 (22): 19482–19487. doi:10.1074/jbc.M201687200. PMID 11909874.

[entrez-7] "Entrez Gene: EGR3 early growth response 3".

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