EIF4A

eukaryotic translation initiation factor 4A, isoform 1
Identifiers
SymbolEIF4A1
Alt. symbolsEIF4A
NCBI gene1973
HGNC3282
OMIM602641
RefSeqNM_001416
UniProtP60842
Other data
LocusChr. 17 p13
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StructuresSwiss-model
DomainsInterPro
eukaryotic translation initiation factor 4A, isoform 2
Identifiers
SymbolEIF4A2
Alt. symbolsEIF4F
NCBI gene1974
HGNC3284
OMIM601102
RefSeqNM_001967
UniProtQ14240
Other data
EC number3.6.1.1
LocusChr. 3 q28
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StructuresSwiss-model
DomainsInterPro
eukaryotic translation initiation factor 4A, isoform 3
Identifiers
SymbolEIF4A3
Alt. symbolsDDX48
NCBI gene9775
HGNC18683
OMIM608546
RefSeqNM_014740
UniProtP38919
Other data
LocusChr. 17 q25.3
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StructuresSwiss-model
DomainsInterPro

The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA.[1][2]

  1. ^ Rogers GW, Komar AA, Merrick WC (2002). eIF4A: the godfather of the DEAD box helicases. Vol. 72. pp. 307–31. doi:10.1016/S0079-6603(02)72073-4. ISBN 9780125400725. PMID 12206455. {{cite book}}: |journal= ignored (help)
  2. ^ Schütz P, Bumann M, Oberholzer AE, Bieniossek C, Trachsel H, Altmann M, Baumann U (Jul 2008). "Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions". Proceedings of the National Academy of Sciences of the United States of America. 105 (28): 9564–9. Bibcode:2008PNAS..105.9564S. doi:10.1073/pnas.0800418105. PMC 2474498. PMID 18606994.