EIF5B

EIF5B
Identifiers
Aliases	EIF5B, IF2, eukaryotic translation initiation factor 5B
External IDs	OMIM: 606086; MGI: 2441772; HomoloGene: 134613; GeneCards: EIF5B; OMA:EIF5B - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	99,401,326 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	38,094,660 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; oocyte; ; secondary oocyte; ; internal globus pallidus; ; myocardium of left ventricle; ; gingival epithelium; ; pericardium; ; pars reticulata; ; cardia; ; external globus pallidus;
	Top expressed in
	tail of embryo; ; lens; ; genital tubercle; ; zygote; ; epithelium of lens; ; secondary oocyte; ; parotid gland; ; lacrimal gland; ; primary oocyte; ; epiblast;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; metal ion binding; GTP binding; hydrolase activity; translation initiation factor activity; RNA binding; GTPase activity;
Cellular component	cytosol; nucleus; cytoplasm;
Biological process	regulation of translational initiation; translational initiation; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	9669
	226982
	ENSG00000158417
	ENSMUSG00000026083
	O60841
	Q05D44
	NM_015904
	NM_198303
	NP_056988
	NP_938045
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.^[5]^[6]^[7]

Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in bacteria which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158417 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026083 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee JH, Choi SK, Roll-Mecak A, Burley SK, Dever TE (May 1999). "Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2". Proc Natl Acad Sci U S A. 96 (8): 4342–7. Bibcode:1999PNAS...96.4342L. doi:10.1073/pnas.96.8.4342. PMC 16334. PMID 10200264.
^ Wilson SA, Sieiro-Vazquez C, Edwards NJ, Iourin O, Byles ED, Kotsopoulou E, Adamson CS, Kingsman SM, Kingsman AJ, Martin-Rendon E (Oct 1999). "Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix". Biochem J. 342. ( Pt 1) (Pt 1): 97–103. doi:10.1042/bj3420097. PMC 1220441. PMID 10432305.
^ ^a ^b "Entrez Gene: EIF5B eukaryotic translation initiation factor 5B".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158417 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026083 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10200264-5] Lee JH, Choi SK, Roll-Mecak A, Burley SK, Dever TE (May 1999). "Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2". Proc Natl Acad Sci U S A. 96 (8): 4342–7. Bibcode:1999PNAS...96.4342L. doi:10.1073/pnas.96.8.4342. PMC 16334. PMID 10200264.

[pmid10432305-6] Wilson SA, Sieiro-Vazquez C, Edwards NJ, Iourin O, Byles ED, Kotsopoulou E, Adamson CS, Kingsman SM, Kingsman AJ, Martin-Rendon E (Oct 1999). "Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix". Biochem J. 342. ( Pt 1) (Pt 1): 97–103. doi:10.1042/bj3420097. PMC 1220441. PMID 10432305.

[entrez-7] "Entrez Gene: EIF5B eukaryotic translation initiation factor 5B".

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