ELAC1

ELAC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZWF
Identifiers
Aliases	ELAC1, D29, elaC ribonuclease Z 1
External IDs	OMIM: 608079; MGI: 1890495; HomoloGene: 10272; GeneCards: ELAC1; OMA:ELAC1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	50,988,121 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	73,887,550 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; Achilles tendon; ; gonad; ; right adrenal gland; ; right lobe of thyroid gland; ; body of pancreas; ; left adrenal gland; ; testicle; ; right adrenal cortex; ; left adrenal cortex;
	Top expressed in
	retinal pigment epithelium; ; lacrimal gland; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; ciliary body; ; substantia nigra; ; central gray substance of midbrain; ; median eminence; ; arcuate nucleus; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nuclease activity; endonuclease activity; 3'-tRNA processing endoribonuclease activity; hydrolase activity; metal ion binding; endoribonuclease activity, producing 5'-phosphomonoesters;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	tRNA 3'-trailer cleavage; RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA processing; tRNA 3'-trailer cleavage, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	55520
	114615
	ENSG00000141642
	ENSMUSG00000036941
	Q9H777
	Q8VEB6
	NM_018696
	NM_053255
	NP_061166
	NP_444485
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc phosphodiesterase ELAC protein 1 is an enzyme that in humans is encoded by the ELAC1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141642 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036941 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takaku H, Minagawa A, Takagi M, Nashimoto M (Apr 2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Res. 31 (9): 2272–8. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.
^ "Entrez Gene: ELAC1 elaC homolog 1 (E. coli)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141642 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036941 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12711671-5] Takaku H, Minagawa A, Takagi M, Nashimoto M (Apr 2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Res. 31 (9): 2272–8. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.

[entrez-6] "Entrez Gene: ELAC1 elaC homolog 1 (E. coli)".

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