ELAC2

ELAC2
Identifiers
Aliases	ELAC2, COXPD17, ELC2, HPC2, elaC ribonuclease Z 2
External IDs	OMIM: 605367; MGI: 1890496; HomoloGene: 6403; GeneCards: ELAC2; OMA:ELAC2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	13,018,065 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	64,892,895 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; apex of heart; ; right adrenal cortex; ; left adrenal gland; ; sural nerve; ; left adrenal cortex; ; gastrocnemius muscle; ; epithelium of colon; ; left ventricle; ; islet of Langerhans;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; perirhinal cortex; ; entorhinal cortex; ; spermatocyte; ; epiblast; ; zygote; ; yolk sac; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endonuclease activity; nuclease activity; hydrolase activity; metal ion binding; tRNA-specific ribonuclease activity; RNA binding; 3'-tRNA processing endoribonuclease activity;
Cellular component	mitochondrial matrix; mitochondrial nucleoid; mitochondrion; nucleus; nucleoplasm;
Biological process	mitochondrial tRNA 3'-trailer cleavage, endonucleolytic; mitochondrial tRNA processing; tRNA 3'-end processing; tRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	60528
	68626
	ENSG00000006744
	ENSMUSG00000020549
	Q9BQ52
	Q80Y81
	NM_173717; NM_001165962; NM_018127
	NM_023479; NM_001362982; NM_001362983; NM_001362984
	NP_001159434; NP_060597; NP_776065
	NP_075968; NP_001349911; NP_001349912; NP_001349913
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc phosphodiesterase ELAC protein 2 is an enzyme that in humans is encoded by the ELAC2 gene.^[5]^[6]^[7] on chromosome 17. It is an endonuclease thought to be involved in mitochondrial tRNA maturation,

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006744 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020549 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rebbeck TR, Walker AH, Zeigler-Johnson C, Weisburg S, Martin AM, Nathanson KL, Wein AJ, Malkowicz SB (Oct 2000). "Association of HPC2/ELAC2 Genotypes and Prostate Cancer". Am J Hum Genet. 67 (4): 1014–9. doi:10.1086/303096. PMC 1287872. PMID 10986046.
^ Noda D, Itoh S, Watanabe Y, Inamitsu M, Dennler S, Itoh F, Koike S, Danielpour D, ten Dijke P, Kato M (September 2006). "ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells". Oncogene. 25 (41): 5591–600. doi:10.1038/sj.onc.1209571. PMID 16636667. S2CID 23413428.
^ "Entrez Gene: ELAC2 elaC homolog 2 (E. coli)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006744 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020549 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10986046-5] Rebbeck TR, Walker AH, Zeigler-Johnson C, Weisburg S, Martin AM, Nathanson KL, Wein AJ, Malkowicz SB (Oct 2000). "Association of HPC2/ELAC2 Genotypes and Prostate Cancer". Am J Hum Genet. 67 (4): 1014–9. doi:10.1086/303096. PMC 1287872. PMID 10986046.

[pmid16636667-6] Noda D, Itoh S, Watanabe Y, Inamitsu M, Dennler S, Itoh F, Koike S, Danielpour D, ten Dijke P, Kato M (September 2006). "ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells". Oncogene. 25 (41): 5591–600. doi:10.1038/sj.onc.1209571. PMID 16636667. S2CID 23413428.

[entrez-7] "Entrez Gene: ELAC2 elaC homolog 2 (E. coli)".

[1]

[2]

[3]

[4]

[5]

[6]

[7]