ELAV-like protein 1

ELAVL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HI9, 4ED5, 4EGL, 4FXV
Identifiers
Aliases	ELAVL1, ELAV1, HUR, Hua, MelG, ELAV like RNA binding protein 1, HuR
External IDs	OMIM: 603466; MGI: 1100851; HomoloGene: 20367; GeneCards: ELAVL1; OMA:ELAVL1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 7,958,573 bp[1] End 8,005,659 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 2.0 cM Start 4,335,382 bp[2] End 4,375,413 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte pericardium mucosa of sigmoid colon ventricular zone corpus epididymis periodontal fiber renal medulla parotid gland caput epididymis Top expressed in endocardial cushion abdominal wall mandibular prominence maxillary prominence somite epiblast atrioventricular valve ventricular zone molar cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity mRNA 3'-UTR binding protein binding RNA binding nucleic acid binding double-stranded RNA binding protein kinase binding mRNA binding mRNA 3'-UTR AU-rich region binding miRNA binding Cellular component cytoplasm cytosol membrane nucleoplasm nucleus ribonucleoprotein complex cytoplasmic stress granule postsynapse glutamatergic synapse Biological process regulation of mRNA stability regulation of stem cell population maintenance positive regulation of translation multicellular organism development mRNA stabilization 3'-UTR-mediated mRNA stabilization mRNA splicing, via spliceosome negative regulation of gene silencing by miRNA protein homooligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1994 15568 Ensembl ENSG00000066044 ENSMUSG00000040028 UniProt Q15717 P70372 RefSeq (mRNA) NM_001419 NM_010485 RefSeq (protein) NP_001410 NP_034615 Location (UCSC) Chr 19: 7.96 – 8.01 Mb Chr 8: 4.34 – 4.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene.^[5][6]

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements in 3' untranslated regions. One of its best-known functions is to stabilize mRNAs in order to regulate gene expression.^[7] Various post-translational modifications of HuR influence its subcellular localization and stability of binding to mRNAs.^[8]