ELK1

ELK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DUX
Identifiers
Aliases	ELK1, ETS transcription factor, ETS transcription factor ELK1
External IDs	OMIM: 311040; MGI: 101833; HomoloGene: 3832; GeneCards: ELK1; OMA:ELK1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 47,635,521 bp[1] End 47,650,604 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A1.3|X 16.45 cM Start 20,799,634 bp[2] End 20,816,847 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb beta cell thoracic diaphragm vena cava glutes cardia body of tongue triceps brachii muscle external globus pallidus cerebellar vermis Top expressed in Rostral migratory stream ciliary body substantia nigra dentate gyrus of hippocampal formation granule cell internal carotid artery fossa cerebellar vermis Paneth cell lobe of cerebellum cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding protein binding double-stranded DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm axon terminus nucleoplasm soma dendrite mitochondrion nucleus Biological process cell differentiation regulation of transcription, DNA-templated response to light stimulus cellular response to testosterone stimulus response to fibroblast growth factor positive regulation of neuron death transcription, DNA-templated positive regulation of transcription, DNA-templated cellular response to gamma radiation cellular response to lipid positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2002 13712 Ensembl ENSG00000126767 ENSMUSG00000009406 UniProt P19419 P41969 RefSeq (mRNA) NM_005229 NM_001114123 NM_001257168 NM_007922 RefSeq (protein) NP_001107595 NP_001244097 NP_005220 NP_031948 Location (UCSC) Chr X: 47.64 – 47.65 Mb Chr X: 20.8 – 20.82 Mb PubMed search [3] [4]
Wikidata
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ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1.^[5] Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences. Elk1 plays important roles in various contexts, including long-term memory formation, drug addiction, Alzheimer's disease, Down syndrome, breast cancer, and depression.