Names | |
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Preferred IUPAC name
N-Ethyl-N-nitrosourea | |
Other names
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Identifiers | |
3D model (JSmol)
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Abbreviations | ENU[citation needed] |
1761174 | |
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.010.975 |
EC Number |
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KEGG | |
PubChem CID
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RTECS number |
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UNII | |
UN number | 2811 |
CompTox Dashboard (EPA)
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Properties | |
C3H7N3O2 | |
Molar mass | 117.108 g·mol−1 |
log P | 0.208 |
Vapor pressure | 0.00244 kPa @ 25˚C[1] |
Acidity (pKa) | 12.317 |
Basicity (pKb) | 1.680 |
Absorbance | ε398 = 11.86 mM−1 cm−1[2] |
Hazards | |
GHS labelling: | |
Danger | |
H301, H312, H332, H350, H360 | |
P280, P308+P313 | |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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300 mg kg−1 (oral, rat) |
Related compounds | |
Related ureas
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Related compounds
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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ENU, also known as N-ethyl-N-nitrosourea (chemical formula C3H7N3O2), is a highly potent mutagen. For a given gene in mice, ENU can induce 1 new mutation in every 700 loci. It is also toxic at high doses.
The chemical is an alkylating agent, and acts by transferring the ethyl group of ENU to nucleobases (usually thymine) in nucleic acids. Its main targets are the spermatogonial stem cells, from which mature sperm are derived.