EP300

EP300
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3
Identifiers
Aliases	EP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK2
External IDs	OMIM: 602700; MGI: 1276116; HomoloGene: 1094; GeneCards: EP300; OMA:EP300 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 41,092,592 bp[1] End 41,180,077 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 81,469,552 bp[2] End 81,536,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon bone marrow cells lower lobe of lung tonsil testicle visceral pleura ventricular zone parietal pleura corpus callosum monocyte Top expressed in tail of embryo genital tubercle gastrula zygote granulocyte mesenteric lymph nodes hand submandibular gland spleen secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein C-terminus binding transcription factor binding transcription coregulator activity metal ion binding acyltransferase activity transferase activity beta-catenin binding pre-mRNA intronic binding zinc ion binding chromatin binding damaged DNA binding protein binding acetyltransferase activity DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription coactivator activity p53 binding androgen receptor binding chromatin DNA binding histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor peptide N-acetyltransferase activity peptide-lysine-N-acetyltransferase activity protein propionyltransferase activity STAT family protein binding peptide butyryltransferase activity histone crotonyltransferase activity histone butyryltransferase activity RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus histone acetyltransferase complex transcription regulator complex nucleoplasm cytoplasm cytosol chromosome Biological process somitogenesis rhythmic process transcription by RNA polymerase II histone H2B acetylation animal organ morphogenesis cell cycle B cell differentiation apoptotic process regulation of transcription, DNA-templated lung development N-terminal peptidyl-lysine acetylation platelet formation stimulatory C-type lectin receptor signaling pathway transcription, DNA-templated positive regulation of transcription, DNA-templated heart development regulation of transcription from RNA polymerase II promoter in response to hypoxia viral process protein acetylation Notch signaling pathway cellular response to UV protein stabilization positive regulation of DNA-binding transcription factor activity negative regulation of transcription by RNA polymerase II nervous system development regulation of autophagy regulation of androgen receptor signaling pathway positive regulation of protein binding positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response fat cell differentiation positive regulation by host of viral transcription megakaryocyte development intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator internal protein amino acid acetylation regulation of cell cycle regulation of tubulin deacetylation positive regulation of gene expression histone H4 acetylation regulation of cellular response to heat transcription-coupled nucleotide-excision repair skeletal muscle tissue development positive regulation of type I interferon production response to estrogen response to hypoxia regulation of signal transduction by p53 class mediator internal peptidyl-lysine acetylation beta-catenin-TCF complex assembly DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest macrophage derived foam cell differentiation circadian rhythm protein deubiquitination positive regulation of transcription by RNA polymerase II protein destabilization regulation of megakaryocyte differentiation histone acetylation epigenetic maintenance of chromatin in transcription-competent conformation peptidyl-lysine propionylation peptidyl-lysine crotonylation peptidyl-lysine butyrylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2033 328572 Ensembl ENSG00000100393 ENSMUSG00000055024 UniProt Q09472 B2RWS6 RefSeq (mRNA) NM_001429 NM_001362843 NM_177821 RefSeq (protein) NP_001420 NP_001349772 NP_808489 Location (UCSC) Chr 22: 41.09 – 41.18 Mb Chr 15: 81.47 – 81.54 Mb PubMed search [3] [4]
Wikidata
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Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene.^[5] It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.

The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein.

EP300 is closely related to another gene, CREB binding protein, which is found on human chromosome 16.