EPHX1

EPHX1
Identifiers
Aliases	EPHX1, EPHX, EPOX, HYL1, MEH, epoxide hydrolase 1
External IDs	OMIM: 132810; MGI: 95405; HomoloGene: 94; GeneCards: EPHX1; OMA:EPHX1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	225,845,563 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,848,469 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; right lobe of liver; ; left ovary; ; right ovary; ; olfactory zone of nasal mucosa; ; right uterine tube; ; bronchial epithelial cell; ; nasal epithelium;
	Top expressed in
	choroid plexus of fourth ventricle; ; left lobe of liver; ; stroma of bone marrow; ; nasal epithelium; ; olfactory epithelium; ; Epithelium of choroid plexus; ; vestibular membrane of cochlear duct; ; right lung lobe; ; iris; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	catalytic activity; hydrolase activity; cis-stilbene-oxide hydrolase activity; epoxide hydrolase activity; enzyme binding;
Cellular component	integral component of membrane; organelle membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle; plasma membrane;
Biological process	cellular aromatic compound metabolic process; xenobiotic metabolic process; aromatic compound catabolic process; response to organic cyclic compound; response to toxic substance; epoxide metabolic process; liver development; diol biosynthetic process; cellular response to organic substance; cellular response to glucocorticoid stimulus;
	Sources:Amigo / QuickGO
Orthologs
	2052
	13849
	ENSG00000143819
	ENSMUSG00000038776
	P07099
	Q9D379
	NM_001291163; NM_000120; NM_001136018
	NM_010145; NM_001312918
NP_000111; NP_001129490; NP_001278092; NP_001365355; NP_001365356;
	NP_001365357; NP_001365358; NP_001365359; NP_001365360; NP_001365361
	NP_001299847; NP_034275
	Wikidata
View/Edit Human	View/Edit Mouse

Epoxide hydrolase 1 is an enzyme encoded by the EPHX1 gene in humans.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143819 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038776 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hartsfield JK, Sutcliffe MJ, Everett ET, Hassett C, Omiecinski CJ, Saari JA (1998). "Assignment1 of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization". Cytogenet. Cell Genet. 83 (1–2): 44–5. doi:10.1159/000015164. PMID 9925921. S2CID 42482323.
^ "Entrez Gene: EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143819 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038776 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9925921-5] Hartsfield JK, Sutcliffe MJ, Everett ET, Hassett C, Omiecinski CJ, Saari JA (1998). "Assignment1 of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization". Cytogenet. Cell Genet. 83 (1–2): 44–5. doi:10.1159/000015164. PMID 9925921. S2CID 42482323.

[entrez-6] "Entrez Gene: EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)".

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