ERAP1

ERAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YD0, 3MDJ, 3QNF, 3RJO
Identifiers
Aliases	ERAP1, A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP, endoplasmic reticulum aminopeptidase 1
External IDs	OMIM: 606832; MGI: 1933403; HomoloGene: 140581; GeneCards: ERAP1; OMA:ERAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	96,808,100 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	74,841,320 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; rectum; ; monocyte; ; epithelium of colon; ; duodenum; ; bone marrow cells; ; epithelium of nasopharynx; ; Achilles tendon; ; mucosa of colon; ; bronchial epithelial cell;
	Top expressed in
	duodenum; ; muscle of thigh; ; jejunum; ; thymus; ; ileum; ; liver; ; tail of embryo; ; spleen; ; white adipose tissue; ; right kidney;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	interleukin-6 receptor binding; peptide binding; zinc ion binding; metal ion binding; interleukin-1, type II receptor binding; peptidase activity; protein binding; aminopeptidase activity; metalloexopeptidase activity; hydrolase activity; metallopeptidase activity; endopeptidase activity; metalloaminopeptidase activity;
Cellular component	cytoplasm; integral component of membrane; cytosol; endoplasmic reticulum membrane; membrane; extracellular region; endoplasmic reticulum; extracellular exosome; extracellular space; endoplasmic reticulum lumen; plasma membrane;
Biological process	regulation of innate immune response; adaptive immune response; response to bacterium; immune system process; antigen processing and presentation of peptide antigen via MHC class I; proteolysis; positive regulation of angiogenesis; membrane protein ectodomain proteolysis; angiogenesis; fat cell differentiation; peptide catabolic process; antigen processing and presentation of endogenous peptide antigen via MHC class I; regulation of blood pressure; signal transduction; cell-cell signaling;
	Sources:Amigo / QuickGO
Orthologs
	51752
	80898
	ENSG00000164307
	ENSMUSG00000021583
	Q9NZ08
	Q9EQH2
	NM_001040458; NM_001198541; NM_016442; NM_001349244
	NM_030711
	NP_001035548; NP_001185470; NP_057526; NP_001336173
	NP_109636
	Wikidata
View/Edit Human	View/Edit Mouse

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that in humans is encoded by the ERAP1 gene. This M1 zinc aminopeptidase is involved in the antigen processing and presentation pathway. ERAP1 is mainly located in the endoplasmic reticulum (ER), where it trims peptides at their N-terminus, adapting them for presentation by MHC class I molecules (MHC-I).^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164307 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021583 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shastri N, Nagarajan N, Lind KC, Kanaseki T (February 2014). "Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum". Current Opinion in Immunology. 26: 123–127. doi:10.1016/j.coi.2013.11.006. PMC 3932006. PMID 24556408.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164307 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021583 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Shastri N, Nagarajan N, Lind KC, Kanaseki T (February 2014). "Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum". Current Opinion in Immunology. 26: 123–127. doi:10.1016/j.coi.2013.11.006. PMC 3932006. PMID 24556408.

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