ERAP2

ERAP2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3SE6, 4E36, 4JBS, 5CU5, 5AB2, 5AB0
Identifiers
Aliases	ERAP2, L-RAP, LRAP, endoplasmic reticulum aminopeptidase 2
External IDs	OMIM: 609497; HomoloGene: 75183; GeneCards: ERAP2; OMA:ERAP2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q15 Start 96,875,986 bp[1] End 96,919,703 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell granulocyte lymph node superficial temporal artery visceral pleura epithelium of nasopharynx monocyte epithelium of colon appendix Achilles tendon n/a More reference expression data BioGPS n/a
Gene ontology Molecular function aminopeptidase activity metallopeptidase activity peptidase activity hydrolase activity zinc ion binding metal ion binding peptide binding metalloaminopeptidase activity endopeptidase activity Cellular component integral component of membrane endoplasmic reticulum lumen endoplasmic reticulum membrane membrane endoplasmic reticulum plasma membrane cytoplasm Biological process immune system process adaptive immune response proteolysis regulation of blood pressure antigen processing and presentation of peptide antigen via MHC class I peptide catabolic process antigen processing and presentation of endogenous peptide antigen via MHC class I signal transduction cell-cell signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64167 n/a Ensembl ENSG00000164308 n/a UniProt Q6P179 n/a RefSeq (mRNA) NM_001130140 NM_022350 NM_001329229 NM_001329233 n/a RefSeq (protein) NP_001123612 NP_001316158 NP_001316162 NP_071745 n/a Location (UCSC) Chr 5: 96.88 – 96.92 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a protein that in humans is encoded by the ERAP2 gene. ERAP2 is part of the M1 aminopeptidase family. It is expressed along with ERAP1 in the endoplasmic reticulum (ER). In the ER, both enzymes help process and present antigens by trimming the ends of precursor peptides. This creates the optimal pieces for display by Major Histocompatibility Complex (MHC) class I molecules.