ETS2

ETS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesETS2, ETS2IT1, ETS proto-oncogene 2, transcription factor
External IDsOMIM: 164740; MGI: 95456; HomoloGene: 3838; GeneCards: ETS2; OMA:ETS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256295
NM_005239

NM_011809

RefSeq (protein)

NP_001243224
NP_005230

NP_035939

Location (UCSC)Chr 21: 38.81 – 38.82 MbChr 16: 95.5 – 95.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein C-ETS2 is a protein that in humans is encoded by the ETS2 gene.[5][6] The protein encoded by this gene belongs to the ETS family of transcription factors.[5] It has been found to play a key role in the development of inflammatory bowel disease.[7][8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157557Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022895Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Dwyer J, Li H, Xu D, Liu JP (Oct 2007). "Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family". Annals of the New York Academy of Sciences. 1114 (1): 36–47. Bibcode:2007NYASA1114...36D. doi:10.1196/annals.1396.022. PMID 17986575. S2CID 44532648.
  6. ^ "Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)".
  7. ^ Chen Y, Ying Y, Wang M, Ma C, Jia M, Shi L, et al. (January 2023). "A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer". Cell Death & Disease. 14 (1): 8. doi:10.1038/s41419-022-05513-1. PMC 9822945. PMID 36609474.
  8. ^ Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, et al. (June 2024). "A disease-associated gene desert directs macrophage inflammation through ETS2". Nature. 630 (8016): 447–456. Bibcode:2024Natur.630..447S. doi:10.1038/s41586-024-07501-1. PMC 11168933. PMID 38839969.