Ebastine

"Aleva" redirects here. For the pepper called "aleva", see Cayenne pepper.
Ebastine
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Pharmacokinetic data
Protein bindingGreater than 95%
MetabolismHepatic (CYP3A4-mediated), to carebastine
Elimination half-life15 to 19 hours (carebastine)
Identifiers
  • 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.106.831 Edit this at Wikidata
Chemical and physical data
FormulaC32H39NO2
Molar mass469.669 g·mol−1
3D model (JSmol)
  • O=C(c1ccc(cc1)C(C)(C)C)CCCN4CCC(OC(c2ccccc2)c3ccccc3)CC4
  • InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3 checkY
  • Key:MJJALKDDGIKVBE-UHFFFAOYSA-N checkY
  (verify)

Ebastine is a H1 antihistamine with low potential for causing drowsiness.

It does not penetrate the blood–brain barrier to a significant amount and thus combines an effective block of the H1 receptor in peripheral tissue with a low incidence of central side effects, i.e. seldom causing sedation or drowsiness.[1][2][3]

It was patented in 1983 by Almirall S.A and came into medical use in 1990.[4] The substance is often provided in micronised form due to poor water solubility.

  1. ^ Cite error: The named reference Tagawa 2001 was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference Arzneistoff-Profile was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Bousquet 1999 was invoked but never defined (see the help page).
  4. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495.