Eisler is a Jewish surname of German origin that may refer to:
- Barry Eisler, American novelist
- Brenda Eisler, Canadian long jumper
- Georg Eisler, Austrian painter
- Gerhart Eisler, German journalist and politician
- Hanns Eisler, Austrian composer
- Jerzy Eisler, Polish historian
- Kim Isaac Eisler, American author
- Lloyd Eisler, Canadian figure skater
- Paul Eisler, Austrian engineer
- Riane Eisler, American sociologist
- Robert Eisler, Austrian Jewish art historian and Biblical scholar