Eldecalcitol

Eldecalcitol
Clinical data
Trade names	Edirol
ATC code	None;
Identifiers
	IUPAC name (1S,2S,3S,5Z,7E)-2-(3-Hydroxypropoxy)-9,10-secocholesta-5,7,10-triene-1,3,25-triol;
CAS Number	104121-92-8;
PubChem CID	6438982;
ChemSpider	4943418;
UNII	I2JP8UE90H;
Chemical and physical data
Formula	C30H50O5
Molar mass	490.725 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@H]1CC(\C(=C)[C@H](O)[C@H]1OCCCO)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CCCC(O)(C)C)C;
	InChI InChI=1S/C30H50O5/c1-20(9-6-15-29(3,4)34)24-13-14-25-22(10-7-16-30(24,25)5)11-12-23-19-26(32)28(27(33)21(23)2)35-18-8-17-31/h11-12,20,24-28,31-34H,2,6-10,13-19H2,1,3-5H3/b22-11+,23-12-/t20-,24-,25+,26+,27+,28+,30-/m1/s1; Key:FZEXGDDBXLBRTD-SJSKTVLPSA-N;

Eldecalcitol is an analog of calcitriol, the active form of vitamin D.^[1]

Commonly used in Japan for the treatment of osteoporosis.^[2] Osteoporosis is a common bone disease among the older generation, with an estimated prevalence of over 200 million people.^[2] This condition often results in bone fractures due to abnormally low bone mass density, and is a leading cause of disability, especially among developed countries with longer average life spans.

^ Hatakeyama S, Yoshino M, Eto K, Takahashi K, Ishihara J, Ono Y, et al. (July 2010). "Synthesis and preliminary biological evaluation of 20-epi-eldecalcitol [20-epi-1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]". The Journal of Steroid Biochemistry and Molecular Biology. 121 (1–2): 25–8. doi:10.1016/j.jsbmb.2010.03.041. PMID 20304058. S2CID 19630314.
^ ^a ^b Sanford M, McCormack PL (September 2011). "Eldecalcitol: a review of its use in the treatment of osteoporosis". Drugs. 71 (13): 1755–70. doi:10.2165/11206790-000000000-00000. PMID 21902297. S2CID 46981685.

[1] Hatakeyama S, Yoshino M, Eto K, Takahashi K, Ishihara J, Ono Y, et al. (July 2010). "Synthesis and preliminary biological evaluation of 20-epi-eldecalcitol [20-epi-1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]". The Journal of Steroid Biochemistry and Molecular Biology. 121 (1–2): 25–8. doi:10.1016/j.jsbmb.2010.03.041. PMID 20304058. S2CID 19630314.

[reviewuse-2] Sanford M, McCormack PL (September 2011). "Eldecalcitol: a review of its use in the treatment of osteoporosis". Drugs. 71 (13): 1755–70. doi:10.2165/11206790-000000000-00000. PMID 21902297. S2CID 46981685.

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