Emodepside

Emodepside
Clinical data
AHFS/Drugs.com	International Drug Names
ATCvet code	QP52AX60 (WHO) (combination with toltrazuril);
Legal status
Legal status	CA: ℞-only;
Identifiers
CAS Number	155030-63-0 ;
PubChem CID	6918632;
ChemSpider	5293825 ;
UNII	YZ647Y5GC9;
ChEBI	CHEBI:78739 ;
ChEMBL	ChEMBL2104404 ;
CompTox Dashboard (EPA)	DTXSID50165799 ;
ECHA InfoCard	100.123.218
Chemical and physical data
Formula	C60H90N6O14
Molar mass	1119.408 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C[C@H]1C(=O)O[C@H](Cc2ccc(N3CCOCC3)cc2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](Cc2ccc(N3CCOCC3)cc2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N1C;
	InChI InChI=1S/C60H90N6O14/c1-37(2)31-47-57(71)77-41(9)53(67)61(11)50(34-40(7)8)60(74)80-52(36-44-17-21-46(22-18-44)66-25-29-76-30-26-66)56(70)64(14)48(32-38(3)4)58(72)78-42(10)54(68)62(12)49(33-39(5)6)59(73)79-51(55(69)63(47)13)35-43-15-19-45(20-16-43)65-23-27-75-28-24-65/h15-22,37-42,47-52H,23-36H2,1-14H3/t41-,42-,47+,48+,49+,50+,51-,52-/m1/s1 ; Key:ZMQMTKVVAMWKNY-YSXLEBCMSA-N ;
	(what is this?) (verify)

Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats^[1] and belongs to the class of drugs known as the octadepsipeptides,^[2] a relatively new class of anthelmintic (research into these compounds began in the early 1990s),^[3] which are suspected to achieve their anti-parasitic effect by a novel mechanism of action due to their ability to kill nematodes resistant to other anthelmintics.^[4]

^ "Profender? Spot-on at a glance". Archived from the original on 2007-01-11. Retrieved 2007-01-10.
^ Willson J, Amliwala K, Harder A, Holden-Dye L, Walker RJ (January 2003). "The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum". Parasitology. 126 (Pt 1): 79–86. doi:10.1017/S0031182002002639. PMID 12613766. S2CID 21831523.
^ Cite error: The named reference Harder_2005 was invoked but never defined (see the help page).
^ Harder A, Schmitt-Wrede HP, Krücken J, Marinovski P, Wunderlich F, Willson J, et al. (September 2003). "Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action". International Journal of Antimicrobial Agents. 22 (3): 318–331. doi:10.1016/S0924-8579(03)00219-X. PMID 13678839.

[1] "Profender? Spot-on at a glance". Archived from the original on 2007-01-11. Retrieved 2007-01-10.

[Willson_2003-2] Willson J, Amliwala K, Harder A, Holden-Dye L, Walker RJ (January 2003). "The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum". Parasitology. 126 (Pt 1): 79–86. doi:10.1017/S0031182002002639. PMID 12613766. S2CID 21831523.

[Harder_2005-3] Cite error: The named reference Harder_2005 was invoked but never defined (see the help page).

[4] Harder A, Schmitt-Wrede HP, Krücken J, Marinovski P, Wunderlich F, Willson J, et al. (September 2003). "Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action". International Journal of Antimicrobial Agents. 22 (3): 318–331. doi:10.1016/S0924-8579(03)00219-X. PMID 13678839.

[1]

[2]

[3]

[4]