Emopamil binding protein

EBP
Identifiers
Aliases	EBP, CDPX2, CHO2, CPX, CPXD, MEND, emopamil binding protein (sterol isomerase), cholestenol delta-isomerase, EBP cholestenol delta-isomerase
External IDs	OMIM: 300205; MGI: 107822; HomoloGene: 4798; GeneCards: EBP; OMA:EBP - orthologs
EC number	5.3.3.5
Gene location (Human)
Chr.	X chromosome (human)
End	48,528,716 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	8,059,751 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; mucosa of transverse colon; ; left adrenal cortex; ; tendon of biceps brachii; ; oocyte; ; gingival epithelium; ; buccal mucosa cell;
	Top expressed in
	left lobe of liver; ; esophagus; ; decidua; ; duodenum; ; jejunum; ; right kidney; ; proximal tubule; ; human kidney; ; left colon; ; pyloric antrum;
	More reference expression data
	n/a
Gene ontology
Molecular function	C-8 sterol isomerase activity; isomerase activity; xenobiotic transmembrane transporter activity; transmembrane signaling receptor activity; cholestenol delta-isomerase activity; steroid delta-isomerase activity; protein binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; integral component of plasma membrane; endoplasmic reticulum; cytoplasmic vesicle; nuclear envelope; nucleus;
Biological process	skeletal system development; steroid metabolic process; sterol biosynthetic process; lipid metabolism; cholesterol metabolic process; cholesterol biosynthetic process via lathosterol; sterol metabolic process; cholesterol biosynthetic process via desmosterol; steroid biosynthetic process; cholesterol biosynthetic process; xenobiotic transmembrane transport; signal transduction; hemopoiesis; xenobiotic transport;
	Sources:Amigo / QuickGO
Orthologs
	10682
	13595
	ENSG00000147155
	ENSMUSG00000031168
	Q15125
	P70245
	NM_006579
	NM_007898
	NP_006570
	NP_031924
	Wikidata
View/Edit Human	View/Edit Mouse

Emopamil binding protein is a protein that in humans is encoded by the EBP gene, located on the X chromosome.^[5] The protein is shown to have a high-affinity reception for anti-ischemic drugs, such as Emopamil, resulting in its discovery and given name. EBP has a mass of 27.3 kDa and resembles the σ₂-receptor that resides in the endoplasmic reticulum of various tissues as an integral membrane protein.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147155 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031168 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Guggenberger C, Ilgen D, Adamski J (May 2007). "Functional analysis of cholesterol biosynthesis by RNA interference". The Journal of Steroid Biochemistry and Molecular Biology. 104 (3–5): 105–109. doi:10.1016/j.jsbmb.2007.03.001. PMID 17498944. S2CID 20838858.
^ Hanner M, Moebius FF, Weber F, Grabner M, Striessnig J, Glossmann H (March 1995). "Phenylalkylamine Ca2+ antagonist binding protein. Molecular cloning, tissue distribution, and heterologous expression". The Journal of Biological Chemistry. 270 (13): 7551–7557. doi:10.1074/jbc.270.13.7551. PMID 7706302.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147155 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031168 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17498944-5] Guggenberger C, Ilgen D, Adamski J (May 2007). "Functional analysis of cholesterol biosynthesis by RNA interference". The Journal of Steroid Biochemistry and Molecular Biology. 104 (3–5): 105–109. doi:10.1016/j.jsbmb.2007.03.001. PMID 17498944. S2CID 20838858.

[Hanner_1995-6] Hanner M, Moebius FF, Weber F, Grabner M, Striessnig J, Glossmann H (March 1995). "Phenylalkylamine Ca2+ antagonist binding protein. Molecular cloning, tissue distribution, and heterologous expression". The Journal of Biological Chemistry. 270 (13): 7551–7557. doi:10.1074/jbc.270.13.7551. PMID 7706302.

[1]

[2]

[3]

[4]

[5]

[6]