Enah/Vasp-like

EVL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QC6
Identifiers
Aliases	EVL, RNB6, Enah/Vasp-like
External IDs	OMIM: 616912; MGI: 1194884; HomoloGene: 56752; GeneCards: EVL; OMA:EVL - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	100,144,236 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	108,654,775 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right hemisphere of cerebellum; ; ganglionic eminence; ; right frontal lobe; ; anterior cingulate cortex; ; lymph node; ; nucleus accumbens; ; prefrontal cortex; ; anterior pituitary; ; caudate nucleus;
	Top expressed in
	mesenteric lymph nodes; ; dorsomedial hypothalamic nucleus; ; Gonadal ridge; ; ganglionic eminence; ; ventricular zone; ; molar; ; lateral hypothalamus; ; habenula; ; mandibular prominence; ; dorsal tegmental nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	profilin binding; SH3 domain binding; protein binding; actin binding;
Cellular component	cytoplasm; cytosol; cell projection; membrane; focal adhesion; cytoskeleton; lamellipodium; phagocytic vesicle;
Biological process	positive regulation of actin filament polymerization; negative regulation of ruffle assembly; actin filament organization; nervous system development; axon guidance; cell surface receptor signaling pathway; animal organ morphogenesis; actin polymerization or depolymerization; protein homotetramerization; negative regulation of epithelial cell migration; positive regulation of stress fiber assembly; actin nucleation; cellular response to interferon-gamma;
	Sources:Amigo / QuickGO
Orthologs
	51466
	14026
	ENSG00000196405
	ENSMUSG00000021262
	Q9UI08
	P70429
	NM_016337; NM_001330221
	NM_001163394; NM_001163395; NM_001163396; NM_007965
	NP_001317150; NP_057421
	NP_001156866; NP_001156867; NP_001156868; NP_031991
	Wikidata
View/Edit Human	View/Edit Mouse

Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021262 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB (Dec 2000). "cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains". J Biol Chem. 275 (46): 36143–51. doi:10.1074/jbc.M006274200. PMID 10945997.
^ Klostermann A, Lutz B, Gertler F, Behl C (Jan 2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain". J Biol Chem. 275 (50): 39647–53. doi:10.1074/jbc.M006316200. PMID 10993894.
^ "Entrez Gene: EVL Enah/Vasp-like".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196405 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021262 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10945997-5] Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB (Dec 2000). "cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains". J Biol Chem. 275 (46): 36143–51. doi:10.1074/jbc.M006274200. PMID 10945997.

[pmid10993894-6] Klostermann A, Lutz B, Gertler F, Behl C (Jan 2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain". J Biol Chem. 275 (50): 39647–53. doi:10.1074/jbc.M006316200. PMID 10993894.

[entrez-7] "Entrez Gene: EVL Enah/Vasp-like".

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