Endothelial activation

Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels.[1] It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the early states of atherosclerosis and sepsis, among others.[2] It is also implicated in the formation of deep vein thrombosis.[3] As a result of activation, enthothelium releases Weibel–Palade bodies.[4]

  1. ^ Li X, Fang P, Li Y, Kuo YM, Andrews AJ, Nanayakkara G, Johnson C, Fu H, Shan H, Du F, Hoffman NE, Yu D, Eguchi S, Madesh M, Koch WJ, Sun J, Jiang X, Wang H, Yang X (June 2016). "Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation". Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (6): 1090–100. doi:10.1161/ATVBAHA.115.306964. PMC 4882253. PMID 27127201.
  2. ^ Alom-Ruiz SP, Anilkumar N, Shah AM (June 2008). "Reactive oxygen species and endothelial activation". Antioxidants & Redox Signaling. 10 (6): 1089–100. doi:10.1089/ars.2007.2007. PMID 18315494.
  3. ^ Bovill EG, van der Vliet A (2011). "Venous valvular stasis-associated hypoxia and thrombosis: what is the link?". Annual Review of Physiology. 73: 527–45. doi:10.1146/annurev-physiol-012110-142305. PMID 21034220.
  4. ^ López JA, Chen J (2009). "Pathophysiology of venous thrombosis". Thrombosis Research. 123 (Suppl 4): S30-4. doi:10.1016/S0049-3848(09)70140-9. PMID 19303501.