Endothelin A receptor

EDNRA
Identifiers
Aliases	EDNRA, ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA, endothelin receptor type A
External IDs	OMIM: 131243; MGI: 105923; HomoloGene: 1478; GeneCards: EDNRA; OMA:EDNRA - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	147,544,954 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	78,451,093 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; seminal vesicula; ; visceral pleura; ; urethra; ; endometrium; ; caput epididymis; ; cardiac muscle tissue of right atrium; ; tibia; ; corpus epididymis; ; stromal cell of endometrium;
	Top expressed in
	genital tubercle; ; Gonadal ridge; ; vas deferens; ; external carotid artery; ; left lung lobe; ; ureter; ; lumbar spinal ganglion; ; atrium; ; dermis; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	endothelin receptor activity; G protein-coupled receptor activity; signal transducer activity; protein binding; phosphatidylinositol phospholipase C activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane;
Biological process	smooth muscle contraction; response to hypoxia; neural crest cell development; vasoconstriction; head development; in utero embryonic development; activation of phospholipase C activity; respiratory gaseous exchange by respiratory system; activation of adenylate cyclase activity; regulation of blood pressure; endothelin receptor signaling pathway; enteric nervous system development; heart development; artery smooth muscle contraction; branching involved in blood vessel morphogenesis; cell population proliferation; signal transduction; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; glucose transmembrane transport; regulation of glucose transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1909
	13617
	ENSG00000151617
	ENSMUSG00000031616
	P25101
	Q61614
	NM_001166055; NM_001256283; NM_001957; NM_001354797
	NM_010332
	NP_001159527; NP_001948; NP_001341726
	NP_034462
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelin receptor type A, also known as ET_A, is a human G protein-coupled receptor.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151617 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031616 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EDNRA endothelin receptor type A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151617 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031616 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EDNRA endothelin receptor type A".

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