Endothelium-derived hyperpolarizing factor

In blood vessels Endothelium-Derived Hyperpolarizing Factor or EDHF is proposed to be a substance and/or electrical signal that is generated or synthesized in and released from the endothelium; its action is to hyperpolarize vascular smooth muscle cells, causing these cells to relax, thus allowing the blood vessel to expand in diameter.^[1]

^ Luksha L, Agewall S, Kublickiene K (February 2009). "Endothelium-derived hyperpolarizing factor in vascular physiology and cardiovascular disease". Atherosclerosis. 202 (2): 330–44. doi:10.1016/j.atherosclerosis.2008.06.008. PMID 18656197.

[Luksha2009-1] Luksha L, Agewall S, Kublickiene K (February 2009). "Endothelium-derived hyperpolarizing factor in vascular physiology and cardiovascular disease". Atherosclerosis. 202 (2): 330–44. doi:10.1016/j.atherosclerosis.2008.06.008. PMID 18656197.

[1]