Enediyne

The enediyne functional group

Calicheamicin: An antitumor antibiotic featuring an enediyne unit

Enediynes are organic compounds containing two triple bonds and one double bond.

Enediynes are most notable for their limited use as antitumor antibiotics (known as enediyne anticancer antibiotics).^[1] They are efficient at inducing apoptosis in cells, but cannot differentiate cancerous cells from healthy cells. Consequently, research is being conducted to increase the specificity of enediyne toxicity.

^ Nicolaou KC, Smith AL, Yue EW (July 1993). "Chemistry and biology of natural and designed enediynes". Proceedings of the National Academy of Sciences of the United States of America. 90 (13): 5881–8. Bibcode:1993PNAS...90.5881N. doi:10.1073/pnas.90.13.5881. PMC 46830. PMID 8327459.

[1] Nicolaou KC, Smith AL, Yue EW (July 1993). "Chemistry and biology of natural and designed enediynes". Proceedings of the National Academy of Sciences of the United States of America. 90 (13): 5881–8. Bibcode:1993PNAS...90.5881N. doi:10.1073/pnas.90.13.5881. PMC 46830. PMID 8327459.

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