Combination of | |
---|---|
Dihydroergocristine | Ergot alkaloid |
Dihydroergocornine | Ergot alkaloid |
alpha-Dihydroergocryptine | Ergot alkaloid |
beta-Dihydroergocryptine | Ergot alkaloid |
Clinical data | |
Other names | Co-dergocrine, dihydroergotoxine |
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Routes of administration | Oral, parenteral |
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Pharmacokinetic data | |
Bioavailability | 25% |
Protein binding | 98–99% |
Metabolism | 50% |
Elimination half-life | 3.5 hours |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.158.718 |
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Ergoloid mesylates (USAN), co-dergocrine mesilate (BAN) or dihydroergotoxine mesylate, trade name Hydergine, is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids (dihydroergocristine, dihydroergocornine, and alpha- and beta-dihydroergocryptine).
It was developed by Albert Hofmann (the discoverer of LSD) for Sandoz (now part of Novartis).