| Erythema multiforme (EM) | |
|---|---|
| Other names | Erythema multiforme minor[1] |
 | |
| Erythema multiforme minor of the hands (note the blanching centers of the lesion) | |
| Specialty | Dermatology |
Erythema multiforme (EM) is a skin condition that appears with red patches evolving into target lesions, typically on both hands.[2][3]
It is a type of erythema possibly mediated by deposition of immune complexes (mostly IgM-bound complexes) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure. It is an uncommon disorder, with peak incidence in the second and third decades of life. The disorder has various forms or presentations, which its name reflects (multiforme, "multiform", from multi- + formis). Target lesions are a typical manifestation. Two types, one mild to moderate and one severe, are recognized (erythema multiforme minor and erythema multiforme major).
Erythema multiforme was first described by von Hebra in 1860.[3]
- ^ "Erythema multiforme: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 16 May 2019.
- ^ Johnstone, Ronald B. (2017). "3. Lichenoid reaction pattern". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. p. 41. ISBN 978-0-7020-6830-0.
- ^ a b James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "7. Erythema and urticaria". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Elsevier. pp. 141–142. ISBN 978-0-323-54753-6.