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| Esau de' Buondelmonti | |
|---|---|
| Despot | |
 Arms of Esau de' Buondelmonti as Despot of Ioannina | |
| Ruler of Epirus | |
| Reign | 1385–1411 |
| Predecessor | Maria Angelina |
| Successor | Giorgio de' Buondelmonti |
| Died | 6 February 1411 |
| Spouse | Maria Angelina Doukaina Palaiologina Irene Spata Jevdokija Balšić |
| Issue | Giorgio de' Buondelmonti |
| House | Buondelmonti |
| Father | Manente Buondelmonti |
| Mother | Lapa Acciaiuoli |
| Religion | Roman Catholicism |
Esau de' Buondelmonti (Greek: Ησαύ Μπουοντελμόντ) was the ruler of Ioannina and its surrounding area (central Epirus) from 1385 until his death in 1411, with the Byzantine title of Despot.