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Pronunciation | /ˌɛstrəˈdaɪoʊl ˈæsəteɪt/ ES-trə-DY-ohl ASS-ə-tayt[1] |
Trade names | Femtrace, Femring, Menoring |
Other names | EA; E2A; E3A; Estradiol 3-acetate |
Routes of administration | By mouth, vaginal (ring)[2] |
Drug class | Estrogen; Estrogen ester |
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ECHA InfoCard | 100.167.088 |
Chemical and physical data | |
Formula | C20H26O3 |
Molar mass | 314.425 g·mol−1 |
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Estradiol acetate (EA), sold under the brand names Femtrace, Femring, and Menoring, is an estrogen medication which is used in hormone therapy for the treatment of menopausal symptoms in women.[3][4][5][6] It is taken by mouth once daily or given as a vaginal ring once every three months.[2]
Side effects of estradiol acetate include breast tenderness, breast enlargement, nausea, headache, and fluid retention.[7][5][6] Estradiol acetate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol.[8][9] It is an estrogen ester and a prodrug of estradiol in the body.[9][8] Because of this, it is considered to be a natural and bioidentical form of estrogen.[9][10]
Estradiol acetate was introduced for medical use in 2001.[11] It is available in the United States and the United Kingdom.[11][3] The formulation for use by mouth has been discontinued in the United States.[12]
pmid17506242
was invoked but never defined (see the help page).Ghosh2010
was invoked but never defined (see the help page).Natural estrogens considered here include: [...] Esters of 17β-estradiol, such as estradiol valerate, estradiol benzoate and estradiol cypionate. Esterification aims at either better absorption after oral administration or a sustained release from the depot after intramuscular administration. During absorption, the esters are cleaved by endogenous esterases and the pharmacologically active 17β-estradiol is released; therefore, the esters are considered as natural estrogens.
pmid15382956
was invoked but never defined (see the help page).Femtrace-FDA
was invoked but never defined (see the help page).