Estradiol hemisuccinate

Estradiol hemisuccinate
Clinical data
Trade names	Eutocol, Hosterona (with progesterone)
Other names	Estradiol succinate; Estradiol 17β-hemisuccinate; Estradiol 17β-succinate
Routes of; administration	By mouth, intramuscular injection
Drug class	Estrogen; Estrogen ester
Identifiers
	IUPAC name 4-{[(17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl]oxy}-4-oxobutanoic acid;
CAS Number	7698-93-3;
PubChem CID	66440;
PubChem SID	99444362;
DrugBank	DB07891;
ChemSpider	59813;
UNII	VQV5064VG6;
ChEMBL	ChEMBL1233274;
PDB ligand	HE7 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID00227770 ;
ECHA InfoCard	100.163.857
Chemical and physical data
Formula	C22H28O5
Molar mass	372.461 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]1CC[C@@H]2OC(=O)CCC(=O)O)O;
	InChI InChI=1S/C22H28O5/c1-22-11-10-16-15-5-3-14(23)12-13(15)2-4-17(16)18(22)6-7-19(22)27-21(26)9-8-20(24)25/h3,5,12,16-19,23H,2,4,6-11H2,1H3,(H,24,25)/t16-,17-,18+,19+,22+/m1/s1; Key:YJPIDPAGJSWWBE-FNIAAEIWSA-N;

Estradiol hemisuccinate (brand name Eutocol), or simply estradiol succinate, also known as estradiol 17β-hemisuccinate, is an estrogen medication and an estrogen ester – specifically, the hemisuccinate ester of estradiol.^[1] It is used as a component of hormone replacement therapy for menopause.^[2] Like other estrogens, estradiol hemisuccinate has been found to have beneficial effects on the skin, with improvement of skin thickness observed.^[2]^[3]

Estradiol hemisuccinate is also a component of estradiol hemisuccinate/progesterone (brand name Hosterona), an injectable preparation used to induce withdrawal bleeding in women with amenorrhea.^[4]^[5]^[6]

^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 897. ISBN 978-1-4757-2085-3.
^ ^a ^b Thompson Z, Maibach HI (2010). "Biological Effects of Estrogen on Skin". In Farage MA, Miller KW (eds.). Textbook of Aging Skin. pp. 361–367 (362). doi:10.1007/978-3-540-89656-2_35. ISBN 978-3-540-89655-5.
^ Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J, Langevin M (February 1994). "A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness". American Journal of Obstetrics and Gynecology. 170 (2): 642–649. doi:10.1016/s0002-9378(94)70242-x. PMID 8116726.
^ "¿Qué es Hosterona y para qué sirve?" [What is Hosterona and what is it for?]. matchmyrx.com (in Spanish). PRX Control Solutions. Archived from the original on 13 April 2019.
^ "Hosterona - Para qué sirve" [Hosterona - What it is for]. Los Medicamentos (in Spanish). 23 November 2012.
^ "HOSTERONA (Hormonoterapia)". Laboratorio GADOR.

[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 897. ISBN 978-1-4757-2085-3.

[ThompsonMaibach2010-2] Thompson Z, Maibach HI (2010). "Biological Effects of Estrogen on Skin". In Farage MA, Miller KW (eds.). Textbook of Aging Skin. pp. 361–367 (362). doi:10.1007/978-3-540-89656-2_35. ISBN 978-3-540-89655-5.

[pmid8116726-3] Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J, Langevin M (February 1994). "A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness". American Journal of Obstetrics and Gynecology. 170 (2): 642–649. doi:10.1016/s0002-9378(94)70242-x. PMID 8116726.

[MatchMyRx-Hosterona-4] "¿Qué es Hosterona y para qué sirve?" [What is Hosterona and what is it for?]. matchmyrx.com (in Spanish). PRX Control Solutions. Archived from the original on 13 April 2019.

[LosMedicamentos-Hosterona-5] "Hosterona - Para qué sirve" [Hosterona - What it is for]. Los Medicamentos (in Spanish). 23 November 2012.

[MiVademecum-Hosterona-6] "HOSTERONA (Hormonoterapia)". Laboratorio GADOR.

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