Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is encoded by the ESRRA (Estrogen Related Receptor Alpha) gene.[5][6] ERRα was originally cloned by DNA sequence homology to the estrogen receptor alpha (ERα, NR3A1),[6] but subsequent ligand binding and reporter-gene transfection experiments demonstrated that estrogens did not regulate ERRα.[7] Currently, ERRα is considered an orphan nuclear receptor.[6][7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000173153 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024955 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ESRRA estrogen-related receptor alpha".
- ^ a b c Giguère V, Yang N, Segui P, Evans RM (January 1988). "Identification of a new class of steroid hormone receptors". Nature. 331 (6151): 91–4. Bibcode:1988Natur.331...91G. doi:10.1038/331091a0. PMID 3267207. S2CID 4275394.
- ^ a b Deblois G, Giguère V (August 2011). "Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1812 (8): 1032–40. doi:10.1016/j.bbadis.2010.12.009. PMID 21172432.