Ethanolamides are chemical compounds which are amides formed from carboxylic acids and ethanolamine. Some ethanolamides are naturally occurring, such as anandamide, palmitoylethanolamide and prostamides, which play physiological roles as lipid neurotransmitters and autacoids.
The crystal structure of the membrane enzyme NAPE-PLD has revealed how these endogenous ethanolamides are generated from cell membranes, and that bile acids play a role in their production.[1]
Ethanolamides can be prepared synthetically by heating esters with ethanolamine.[2]
- ^ Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G (Dec 2014). "Structure of Human N-Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids". Structure. 23 (3): 598–604. doi:10.1016/j.str.2014.12.018. PMC 4351732. PMID 25684574.
- ^ Phillips, Arthur P. (1951). "Ethanolamides of Some Mono- and Dicarboxylic Acids". Journal of the American Chemical Society. 73: 5557–5559. doi:10.1021/ja01156a013.