 | |
 | |
| Combination of | |
|---|---|
| Ethinylestradiol | Estrogen |
| Cyproterone acetate | Progestogen; Antiandrogen |
| Clinical data | |
| Trade names | Diane, Diane-35, others |
| Other names | EE/CPA; Co-cyprindiol; SHB 209 AB; SHB 209 AE; SH-81041 |
| Routes of administration | By mouth |
| Drug class | Estrogen; Progestogen; Antiandrogen |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
Ethinylestradiol/cyproterone acetate (EE/CPA), also known as co-cyprindiol and sold under the brand names Diane and Diane-35 among others, is a combination of ethinylestradiol (EE), an estrogen, and cyproterone acetate (CPA), a progestin and antiandrogen, which is used as a birth control pill to prevent pregnancy in women.[2] It is also used to treat androgen-dependent conditions in women such as acne, seborrhea, excessive facial/body hair growth, scalp hair loss, and high androgen levels associated with ovaries with cysts.[3][4][5][6][7][8] The medication is taken by mouth once daily for 21 days, followed by a 7-day free interval.[2]
- ^ "List of nationally authorised medicinal products" (PDF). European Medicines Agency.
- ^ a b "Diane 35 Label" (PDF). Bayer. Archived from the original (PDF) on 2020-11-12.
- ^ Miller JA, Jacobs HS (May 1986). "Treatment of hirsutism and acne with cyproterone acetate". Clinics in Endocrinology and Metabolism. 15 (2): 373–389. doi:10.1016/S0300-595X(86)80031-7. PMID 2941191.
- ^ Hammerstein J (1990). "Antiandrogens: Clinical Aspects". In Orfanos CE, Happle R (eds.). Hair and Hair Diseases. Springer. pp. 827–886. doi:10.1007/978-3-642-74612-3_35. ISBN 978-3-642-74614-7.
- ^ Van der Spuy ZM, le Roux PA (2003). "Cyproterone acetate for hirsutism". The Cochrane Database of Systematic Reviews. 2003 (4): CD001125. doi:10.1002/14651858.CD001125. PMC 8955083. PMID 14583927.
- ^ Jing Z, Liang-Zhi X, Tai-Xiang W, Ying T, Yu-Jian J (October 2008). "The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review". Gynecological Endocrinology. 24 (10): 590–600. doi:10.1080/09513590802288242. PMID 19012104. S2CID 38997400.
- ^ Bitzer J, Römer T, Lopes da Silva Filho A (June 2017). "The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review". The European Journal of Contraception & Reproductive Health Care. 22 (3): 172–182. doi:10.1080/13625187.2017.1317339. PMID 28447864.
- ^ Ruan X, Kubba A, Aguilar A, Mueck AO (June 2017). "Use of cyproterone acetate/ethinylestradiol in polycystic ovary syndrome: rationale and practical aspects". The European Journal of Contraception & Reproductive Health Care. 22 (3): 183–190. doi:10.1080/13625187.2017.1317735. PMID 28463030.