Eukaryotic initiation factor 3

Structure of rabbit eIF3 in the context of the 43S PIC, showing subunits a, c, e, f, h, k, l, and m.[1]

Eukaryotic initiation factor 3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation.[2] It is essential for most forms of cap-dependent and cap-independent translation initiation. In humans, eIF3 consists of 13 nonidentical subunits (eIF3a-m) with a combined molecular weight of ~800 kDa, making it the largest translation initiation factor.[3] The eIF3 complex is broadly conserved across eukaryotes, but the conservation of individual subunits varies across organisms. For instance, while most mammalian eIF3 complexes are composed of 13 subunits, budding yeast's eIF3 has only six subunits (eIF3a, b, c, g, i, j).[4]

  1. ^ des Georges, Amedee; Dhote, Vidya; Kuhn, Lauriane; Hellen, Christopher U.T.; Pestova, Tatyana V.; Frank, Joachim; Hashem, Yaser (2015). "Structure of mammalian eIF3 in the context of the 43S preinitiation complex". Nature. 525 (1770): 491–5. Bibcode:2015Natur.525..491D. doi:10.1038/nature14891. ISSN 0028-0836. PMC 4719162. PMID 26344199.
  2. ^ Aitken, Colin E.; Lorsch, Jon R. (2012). "A mechanistic overview of translation initiation in eukaryotes". Nat. Struct. Mol. Biol. 19 (6): 568–576. doi:10.1038/nsmb.2303. PMID 22664984. S2CID 9201095.
  3. ^ Hershey, John W.B. (2015). "The role of eIF3 and its individual subunits in cancer". Biochim. Biophys. Acta. 1849 (7): 792–800. doi:10.1016/j.bbagrm.2014.10.005. ISSN 1874-9399. PMID 25450521.
  4. ^ Hinnebusch, Alan G. (2006). "eIF3: a versatile scaffold for translation initiation complexes". Trends Biochem. Sci. 31 (10): 553–562. doi:10.1016/j.tibs.2006.08.005. ISSN 0968-0004. PMID 16920360.