Eupolemus Simalou (in Ancient Greek: Eυπόλεμoς Σίμαλου) was a Macedonian officer in the fourth century BC. He would serve the Antipatrids as a strategos during the later Wars of the Diadochi. Scholarship suggests that he would act as a deputy to Cassander's brother, Pleistarchus, and would succeed him in the rule of Caria.