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| Route information | |
| Length | 4,480 km (2,780 mi) |
| Major junctions | |
| North-West end | Samara, Russia |
| Oral Atyrau Beyneu Türkmenbaşy | |
| South-East end | Gyzylarbat, Turkmenistan |
| Location | |
| Countries |  Russia Kazakhstan Turkmenistan |
| Highway system | |
European Route E121 is a European A class road in Russia, Kazakhstan and Turkmenistan, connecting the cities Samara - Oral - Atyrau - Beyneu - Türkmenbaşy