Evidence-based Toxicology Collaboration

The non-profit Evidence-based Toxicology Collaboration (EBTC) comprises a group of scientists and experts with ties to governmental and non-governmental agencies, chemical and pharmaceutical companies, and academia that have banded together to promote the use of what are known as "evidence-based approaches" in toxicology.[1] The discipline of evidence-based toxicology (EBT) is a process for transparently, consistently, and objectively assessing available scientific evidence in order to answer questions in toxicology.[2] EBT has the potential to address concerns in the toxicological community about the limitations of current approaches.[1] These include concerns related to transparency in decision making, synthesis of different types of evidence, and the assessment of bias and credibility.[3][4][5] The evidence-based methods and approaches now being proposed for toxicology are widely used in medicine, which is the basis for their nomenclature.[6] The need to improve how the performance of toxicological test methods is assessed was the main impetus for translating these tools to toxicology.[7]

  1. ^ a b Stephens, M.; Andersen, M.; Becker, R.A.; Betts, K.; et al. (2013). "Evidence-based toxicology for the 21st century: Opportunities and challenges". ALTEX. 30 (1): 74–104. doi:10.14573/altex.2013.1.074. PMID 23338808.
  2. ^ Hoffmann, S.; Hartung, T (2006). "Toward an evidence-based toxicology". Hum Exp Toxicol. 25 (9): 497–513. doi:10.1191/0960327106het648oa. PMID 17017003. S2CID 42202416.
  3. ^ Schreider, J.; Barrow, C.; Birchfield, N.; et al. (2010). "Enhancing the credibility of decisions based on scientific conclusions: transparency is imperative". Toxicol Sci. 116 (1): 5–7. doi:10.1093/toxsci/kfq102. PMID 20363830.
  4. ^ Adami, H.O.; Berry, S.C.; Breckenridge, C.B.; Smith, L.L.; et al. (2011). "Toxicology and epidemiology: improving the science with a framework for combining toxicological and epidemiological evidence to establish causal inference". Toxicol Sci. 122 (2): 223–234. doi:10.1093/toxsci/kfr113. PMC 3155086. PMID 21561883.
  5. ^ Conrad, J.W.; Becker, R.A. (2011). "Enhancing credibility of chemical safety studies: an emerging consensus on key assessment criteria". Environ Health Perspect. 119 (6): 757–764. doi:10.1289/ehp.1002737. PMC 3114808. PMID 21163723.
  6. ^ Eddy, D.M. (2005). "Evidence-Based Medicine: A Unified Approach". Health Aff. 24 (1): 9–17. doi:10.1377/hlthaff.24.1.9. PMID 15647211.
  7. ^ Hoffmann, S.; Hartung, T (2005). "Diagnosis: toxic! Trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations". Toxicol Sci. 85 (1): 422–428. doi:10.1093/toxsci/kfi099. PMID 15689419.