Exemestane

Exemestane

Clinical data
Pronunciation	/ˌɛksəˈmɛˌsteɪn/ EK-sə-ME-stayn
Trade names	Aromasin
Other names	FCE-24304
AHFS/Drugs.com	Monograph
MedlinePlus	a607006
Routes of administration	By mouth
Drug class	Aromatase inhibitor; Antiestrogen
ATC code	L02BG06 (WHO)
Legal status
Legal status	UK: POM (Prescription only)[1] US: ℞-only
Pharmacokinetic data
Bioavailability	~60%[citation needed]
Protein binding	90%
Metabolism	Liver (CYP3A4, aldo-keto reductase)
Elimination half-life	24 hours
Duration of action	4–5 days[citation needed]
Excretion	Urine and feces ~ 1:1 (mainly metabolites)
Identifiers
IUPAC name 6-Methylideneandrosta-1,4-diene-3,17-dione[2]
CAS Number	107868-30-4 Y
PubChem CID	60198
IUPHAR/BPS	7073
DrugBank	DB00990 Y
ChemSpider	54278 Y
UNII	NY22HMQ4BX
KEGG	D00963 Y
ChEBI	CHEBI:4953 N
ChEMBL	ChEMBL1200374 Y
CompTox Dashboard (EPA)	DTXSID5023037
ECHA InfoCard	100.171.149
Chemical and physical data
Formula	C20H24O2
Molar mass	296.410 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C\1\C=C/[C@]3(C(=C/1)/C(=C)C[C@H]4[C@@H]2CCC(=O)[C@]2(CC[C@H]34)C)C
InChI InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1 Y Key:BFYIZQONLCFLEV-DAELLWKTSA-N Y
NY (what is this?)  (verify)

Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive, hormonally-responsive, or hormone-receptor-positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers.