An exosite is a secondary binding site, remote from the active site, on an enzyme or other protein.[1]
This is similar to allosteric sites, but differs in the fact that, in order for an enzyme to be active, its exosite typically must be occupied.[2] Exosites have recently become a topic of increased interest in biomedical research as potential drug targets.[3][4]
^Yegneswaran, S.; Tiefenbrunn, T. K.; Fernández, J. A.; Dawson, P. E. (October 2007). "Manipulation of thrombin exosite I, by ligand-directed covalent modification". Journal of Thrombosis and Haemostasis. 5 (10): 2062–2069. doi:10.1111/j.1538-7836.2007.02712.x. PMID17883702. S2CID38198958.