Exosome component 3

EXOSC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC3, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10, CGI-102, Exosome component 3
External IDs	OMIM: 606489; MGI: 1913612; HomoloGene: 6867; GeneCards: EXOSC3; OMA:EXOSC3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	37,832,117 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	45,342,732 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; tendon of biceps brachii; ; Achilles tendon; ; right testis; ; left testis; ; gonad; ; stromal cell of endometrium; ; sperm; ; ganglionic eminence;
	Top expressed in
	tail of embryo; ; genital tubercle; ; embryo; ; embryo; ; yolk sac; ; epiblast; ; zygote; ; spermatid; ; ventricular zone; ; interventricular septum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3'-5'-exoribonuclease activity; exoribonuclease activity; protein binding; RNA binding;
Cellular component	cytosol; nuclear exosome (RNase complex); cytoplasmic exosome (RNase complex); nucleus; cytoplasm; exosome (RNase complex); nucleolus; nucleoplasm;
Biological process	nuclear polyadenylation-dependent tRNA catabolic process; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of mRNA stability; polyadenylation-dependent snoRNA 3'-end processing; DNA deamination; CUT catabolic process; nuclear polyadenylation-dependent rRNA catabolic process; positive regulation of isotype switching; isotype switching; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; U4 snRNA 3'-end processing; rRNA processing; exonucleolytic catabolism of deadenylated mRNA;
	Sources:Amigo / QuickGO
Orthologs
	51010
	66362
	ENSG00000107371
	ENSMUSG00000028322
	Q9NQT5
	Q7TQK4
	NM_016042; NM_001002269
	NM_025513; NM_001362788
	NP_001002269; NP_057126
	NP_079789; NP_001349717
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome component 3, also known as EXOSC3, is a human gene, which is part of the exosome complex.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107371 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028322 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EXOSC3 exosome component 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107371 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028322 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EXOSC3 exosome component 3".

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