Exosome component 7

EXOSC7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC7, EAP1, RRP42, Rrp42p, hRrp42p, p8, Exosome component 7
External IDs	OMIM: 606488; MGI: 1913696; HomoloGene: 8994; GeneCards: EXOSC7; OMA:EXOSC7 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	45,036,066 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	122,965,194 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; thoracic diaphragm; ; skin of leg; ; right adrenal gland; ; left adrenal gland; ; skin of abdomen; ; left adrenal cortex; ; right adrenal cortex; ; body of tongue;
	Top expressed in
	otic placode; ; morula; ; saccule; ; otic vesicle; ; primitive streak; ; embryo; ; epiblast; ; yolk sac; ; somite; ; blastocyst;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	3'-5'-exoribonuclease activity; exoribonuclease activity; protein binding; RNA binding;
Cellular component	cytoplasm; cytosol; exosome (RNase complex); nucleolus; nucleoplasm; nucleus; nuclear exosome (RNase complex); cytoplasmic exosome (RNase complex);
Biological process	regulation of mRNA stability; RNA catabolic process; rRNA processing; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; U1 snRNA 3'-end processing; U4 snRNA 3'-end processing; U5 snRNA 3'-end processing; exonucleolytic catabolism of deadenylated mRNA; nuclear mRNA surveillance; nuclear polyadenylation-dependent rRNA catabolic process; nuclear polyadenylation-dependent tRNA catabolic process; nuclear polyadenylation-dependent mRNA catabolic process; rRNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23016
	66446
	ENSG00000075914
	ENSMUSG00000025785
	Q15024
	Q9D0M0
	NM_015004
	NM_001081188; NM_025568
	NP_055819
	NP_001074657
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosome complex.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075914 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025785 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EXOSC7 exosome component 7".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075914 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025785 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EXOSC7 exosome component 7".

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