Exosome component 8

EXOSC8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC8, CIP3, EAP2, OIP2, RRP43, Rrp43p, bA421P11.3, p9, PCH1C, Exosome component 8
External IDs	OMIM: 606019; MGI: 1916889; HomoloGene: 12323; GeneCards: EXOSC8; OMA:EXOSC8 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	37,025,881 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	54,642,814 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; right uterine tube; ; gonad; ; left ovary; ; right ovary; ; right testis; ; left testis; ; body of uterus; ; canal of the cervix;
	Top expressed in
	yolk sac; ; tail of embryo; ; genital tubercle; ; blastocyst; ; primitive streak; ; morula; ; medial ganglionic eminence; ; endothelial cell of lymphatic vessel; ; ventricular zone; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	exoribonuclease activity; protein binding; RNA binding; identical protein binding; mRNA 3'-UTR AU-rich region binding;
Cellular component	cytoplasm; cytosol; exosome (RNase complex); nucleolus; nucleus; nucleoplasm; nuclear exosome (RNase complex); cytoplasmic exosome (RNase complex);
Biological process	regulation of mRNA stability; RNA processing; RNA catabolic process; rRNA processing; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; U1 snRNA 3'-end processing; U4 snRNA 3'-end processing; U5 snRNA 3'-end processing; exonucleolytic catabolism of deadenylated mRNA; nuclear mRNA surveillance; nuclear polyadenylation-dependent rRNA catabolic process; nuclear polyadenylation-dependent tRNA catabolic process; nuclear polyadenylation-dependent mRNA catabolic process; biological process; rRNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11340
	69639
	ENSG00000120699
	ENSMUSG00000027752
	Q96B26
	Q9D753
	NM_181503
	NM_001163570; NM_027148
	NP_852480
	NP_001157042; NP_081424
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the exosome complex.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120699 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027752 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EXOSC8 exosome component 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120699 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027752 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EXOSC8 exosome component 8".

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